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Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting
Alkan HF, Walter KE, Luengo A, Madreiter-Sokolowski CT, Stryeck S, Lau AN, Al-Zoughbi W, Lewis CA, Thomas CJ, Hoefler G, Graier WF, Madl T, Vander Heiden MG, Bogner-Strauss JG.
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Aspartate is an endogenous metabolic limitation for tumour growth
Sullivan LB, Luengo A, Danai LV, Bush LN, Diehl FF, Hosios AM, Lau AN, Elmiligy S, Malstrom S, Lewis CA, Vander Heiden MG.
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Altered exocrine function can drive adipose wasting in early pancreatic cancer
Danai LV, Babic A, Rosenthal MH, Dennstedt EA, Muir A, Lien EC, Mayers JR, Tai K, Lau AN, Jones-Sali P, Prado CM, Petersen GM, Takahashi N, Sugimoto M, Yeh JJ, Lopez N, Bardeesy N, Fernandez-Del Castillo C, Liss AS, Koong AC, Bui J, Yuan C, Welch MW, Brais LK, Kulke MH, Dennis C, Clish CB, Wolpin BM, Vander Heiden MG.
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Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma
Dayton TL, Gocheva V, Miller KM, Bhutkar A, Lewis CA, Bronson RT, Vander Heiden MG, Jacks T.
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The redox requirements of proliferating mammalian cells
Hosios AM, Vander Heiden MG.
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PKM2 is not required for colon cancer initiated by APC loss
Lau AN, Israelsen WJ, Roper J, Sinnamon MJ, Georgeon L, Dayton TL, Hillis AL, Yilmaz OH, Di Vizio D, Hung KE, Vander Heiden MG.
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Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition
Muir A, Danai LV, Gui DY, Waingarten CY, Lewis CA, Vander Heiden MG.
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Direct evidence for cancer cell-autonomous extracellular protein catabolism in pancreatic tumors
Davidson SM, Jonas O, Keibler MA, Hou H, Luengo A, Mayers JM, Wyckoff J, Del Rosario A, Whitman M, Chin CR, Condon KJ, Lammers A, Kellersberger KA, Stall BJ, Stephanopolous G, Bar-Sagi D, Han J, Rabinowitz JD, Cima M, Langer R, Vander Heiden MG.
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Environment dictates dependence on mitochondrial complex I for NAD+ and aspartate production and determines cancer cell sensitivity to metformin
Gui DY, Sullivan LB, Luengo A, Hosios AM, Bush, LN, Gitego N, Davidson SM, Freinkman E, Thomas CJ, Vander Heiden MG
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Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
Mayers JR, Torrence ME, Danai LV, Papagiannakopoulos T, Davidson SM, Bauer MR, Lau AN, Ji BW, Dixit PD, Hosios AM, Muir A, Chin CR, Freinkman E, Jacks T, Wolpin BM, Vitkup D, Vander Heiden MG.
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Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells
Hosios AM, Hecht VC, Johnson MO, Rathmel JC, Manalis SR, Vander Heiden MG.
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Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small CellLung Cancer
Davidson SM, Papagiannakopoulos T, Olenchock BA, Luengo A, Heyman JE, Keibler MA, Bauer MR, O’Brien JP, Pierce KA, Gui DY, Wasylenko TM, Mott BT, Chin CR, Stephanopolous G, Jacks T, Clish CB, Vander Heiden MG.
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Lack of evidence for PKM2 protein kinase activity
Hosios AM, Fiske BP, Gui DY, Vander Heiden MG.
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Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells
Sullivan LB, Gui DY Hosios AM, Bush LN, Freinkman E, Vander Heiden MG.
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An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation
Mattaini KR, Brignole EJ, Kini M, Davidson SM, Fiske BP, Drennan CL, Vander Heiden MG.
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Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation
Lunt SY, Muralidhar V., Hosios AM, Israelsen WJ, Gui DY, Newhouse L, Ogrodzinski M, Hecht V, Xu K, Marin Acevedo PN, Hollern DP, Bellinger G, Dayton TL, Christen S, Elia I, Dinh AT, Stephanopoulos G, Manalis SR, Yaffe MB, Andrechek ER, Fendt S-M, Vander Heiden MG.
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Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development
Mayers JR, Wu C, Clish CB, Kraft P, Torrence ME, Fiske BP, Yuan C, Bao Y, Townsend MK, Tworoger SS, Davidson SM, Papagiannakopoulos T, Yang A, Dayton TL, Ogino S, Stampfer MJ, Giovannucci EL, Qian ZR, Rubinson DA, Ma J, Sesso HD, Gaziano JM, Cochrane BB, Liu S, Wactawski-Wende J, Manson JE, Pollak MN, Kimmelman AC, Souza A, Pierce K, Wang TJ, Gerszten RE, Fuchs CS, Vander Heiden MG*, Wolpin BM*.
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Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells
Lewis CA, Parker SJ, Fiske BP, McCloskey D, Gui DY, Green CR, Vokes, NI, Feist AM, Vander Heiden MG*, Metallo CM*.
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PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells
Israelsen WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW, Burga LN, Xie J, Jurczak MJ, Depinho RA, Clish C, Jacks T, Kibbey RG, Wulf GM, DiVizio D, Mills GB, Cantley LC, Vander Heiden MG.
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Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism
Fendt S-M, Bell EL, Keibler MA, Davidson SM, Wirth GJ, Fiske BP, Mayers JR, Blouin MJ, Bellinger G, Csibi A, Patnaik A, Cantley LC, Guarente L, Blenis J, Schwab M, Pollak MN, Olumi AF, Vander Heiden MG*, Stephanopoulos G*.
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