Publications – Vander Heiden Lab

Recent Publications

Cancer tissue of origin constrains the growth and metabolism of metastases

Sharanya Sivanand, Yetis Gultekin, Peter S. Winter, Sidney Y. Vermeulen, Konstantine M. Tchourine, Keene L. Abbott, Laura V. Danai, Florian Gourgue, Brian T. Do, Kayla Crowder, Tenzin Kunchok, Allison N. Lau, Alicia M. Darnell, Alexandria Jefferson, Satoru Morita, Dan G. Duda, Andrew J. Aguirre, Brian M. Wolpin, Nicole Henning, Virginia Spanoudaki, Laura Maiorino, Darrell J. Irvine, Omer H. Yilmaz, Caroline A. Lewis, Matthew G. Vander Heiden

Nat Metab. Sep;6(9):1668-1681. doi: 10.1038/s42255-024-01105-9. (2024)
Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

Brian T. Do, Peggy P. Hsu, Sidney Y. Vermeulen, Zhishan Wang, Taghreed Hirz, Keene L. Abbott, Najihah Aziz, Joseph M. Replogle, Stefan Bjelosevic, Jonathan Paolino, Samantha A. Nelson, Samuel Block, Alicia M. Darnell, Raphael Ferreira, Hanyu Zhang, Jelena Milosevic, Daniel R. Schmidt, Christopher Chidley, Isaac S. Harris, Jonathan S. Weissman, Matthew G. Vander Heiden

Dev Cell. 31 May 2024, https://doi.org/10.1016/j.devcel.2024.05.010 (2024)
Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

Keene L Abbott, Ahmed Ali, Bradley I Reinfeld, Amy Deik, Sonu Subudhi, Madelyn D Landis, Rachel A Hongo, Kirsten L Young, Tenzin Kunchok, Christopher S Nabel, Kayla D Crowder, Johnathan R Kent, Maria Lucia L Madariaga, Rakesh K Jain, Kathryn E Beckermann, Caroline A Lewis, Clary B Clish, Alexander Muir, W Kimryn Rathmell, Jeffrey Rathmell, Matthew G Vander Heiden
Elife. May 24:13:RP95652. doi: 10.7554/eLife.95652. (2024)
Screening in serum-derived medium reveals differential response to compounds targeting metabolism

Abbott KL, Ali A, Casalena D, Do BT, Ferreira R, Cheah JH, Soule CK, Deik A, Kunchok T, Schmidt DR, Renner S, Honeder SE, Wu M, Chan SH, Tseyang T, Stoltzfus AT, Michel SLJ, Greaves D, Hsu PP, Ng CW, Zhang CJ, Farsidjani A, Kent JR, Madariaga MLL, Gramatikov IMT, Matheson NJ, Lewis CA, Clish CB, Rees MG, Roth JA, Griner LM, Muir A, Auld DS, Vander Heiden MG.

Cell Chem Biol. Sep 21;30(9):1156-1168.e7. doi: 10.1016/j.chembiol.2023.08.007. (2023)
Nucleotide imbalance decouples cell growth from cell proliferation

Diehl FF, Miettinen TP, Elbashir R, Nabel CS, Darnell AM, Do BT, Manalis SR, Lewis CA, Vander Heiden MG.

Nat Cell Biol. Aug;24(8):1252-1264 (2022).
Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

Davidson SM, Schmidt DR, Heyman JE, O’Brien JP, Liu AC, Israelsen WJ, Dayton TL, Sehgal R, Bronson RT, Freinkman E, Mak HH, Fanelli GN, Malstrom S, Bellinger G, Carracedo A, Pandolfi PP, Courtney KD, Jha A, DePinho RA, Horner JW, Thomas CJ, Cantley LC, Loda M, Vander Heiden MG.

Cancer Res. Jul 5;82(13):2403-2416. (2022).
Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited

Li Z, Ji BW, Dixit PD, Tchourine K, Lien EC, Hosios AM, Abbott KL, Rutter JC, Westermark AM, Gorodetsky EF, Sullivan LB, Vander Heiden MG, Vitkup D.

Nat Metab. Jun;4(6):711-723 (2022).
Interactions with stromal cells promote a more oxidized cancer cell redox state in pancreatic tumors

Datta R, Sivanand S, Lau AN, Florek LV, Barbeau AM, Wyckoff J, Skala MC, Vander Heiden MG

Sci Adv. Jan 21;8(3):eabg6383 (2022).
Methionine synthase is essential for cancer cell proliferation in physiological folate environments

Sullivan MR, Darnell AM, Reilly MF, Lewis CA, Vander Heiden MG.

Nat Metab. Nov;3(11):1500-1511. (2021).
Low glycaemic diets alter lipid metabolism to influence tumour growth

Lien EC, Westermark AM, Zhang Y, Yuan C, Li Z, Lau AN, Sapp KM, Wolpin BM, Vander Heiden MG.

Nature. Oct 20. doi: 10.1038/s41586-021-04049-2. (2021).

More Publications

Fatty acid synthesis is required for breast cancer brain metastasis

Ferraro GB, Ali A, Luengo A, Kodack DP, Deik A, Abbott KL, Bezwada D, Blanc L, Prideaux B, Jin X, Possada JM, Chen J, Chin CR, Amoozgar Z, Ferreira R, Chen I, Naxerova K, Ng C, Westermark AM, Duquette M, Roberge S, Lindeman NI, Lyssiotis CA, Nielsen J, Housman DE, Duda DG, Brachtel E, Golub TR, Cantley LC, Asara JM, Davison SM, Fukumura D, Dartois VA, Clish CB, Jain RK, Vander Heiden MG

Nat Cancer. Apr;2(4):414-428 (2021).
A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments

Chidley C, Darnell AM, Gaudio BL, Lien EC, Barbeau AM, Vander Heiden MG, Sorger PK.

Nat Cell Biol. Apr 11 (2024)
Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma

Lau AN, Li Z, Danai LV, Westermark AM, Darnell AM, Ferreira R, Gocheva V, Sivanand S, Lien EC, Sapp KM, Mayers JR, Biffi G, Chin CR, Davidson SM, Tuveson DA, Jacks T, Matheson NJ, Yilmaz O, Vander Heiden MG.

Elife. Jul 10;9:e56782. doi: 10.7554/eLife.56782 (2020).
Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer

Luengo A, Abbott KL, Davidson SM, Hosios AM, Faubert B, Chan SH, Freinkman E, Zacharias LG, Mathews TP, Clish CB, DeBerardinis RJ, Lewis CA, Vander Heiden MG.

Nat Commun. Dec 6;10(1):5604 (2019).
Cellular redox state constrains serine synthesis and nucleotide production to impact cell proliferation

Diehl FF, Lewis CA, Fiske BP, Vander Heiden MG.

Nat Metab. Sept 16; 1(861-867) (2019).
Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

Sullivan MR, Danai LV, Lewis CA, Chan SH, Gui DY, Kunchok T, Dennstedt EA, Vander Heiden MG, Muir A.

Elife. Apr 16;8 (2019).
Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting

Sullivan MR, Mattaini KR, Dennstedt EA, Nguyen AA, Sivanand S, Reilly MF, Meeth K, Muir A, Darnell AM, Bosenberg MW, Lewis CA, Vander Heiden MG.

Cell Metab. Jun 4;29(6):1410-1421 (2019).
Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity

Liu VM, Howell AJ, Hosios AM, Li Z, Israelsen WJ, Vander Heiden MG.

FEBS Lett. Oct 23. doi: 10.1002/1873-3468.13648 (2019).
Increased PHGDH expression promotes aberrant melanin accumulation

Mattaini KR, Sullivan MR, Lau AN, Fiske BP, Bronson RT, Vander Heiden MG.

BMC Cancer. Jul 22;19(1):723 (2019).
PKM2 is not required for pancreatic ductal adenocarcinoma

Hillis AL, Lau AN, Devoe CX, Dayton TL, Danai LV, Di Vizio D, Vander Heiden MG.

Cancer Metab. Oct 23;6:17 (2018).

See full list of Matt Vander Heiden Publications on the National Library of Medicine website